Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Alzheimer's disease (AD) is the most common cause of memory impairment and dementia in
the elderly. AD is pathologically characterized by extracellular deposits of beta-amyloid (Aβ) …

Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models
of Alzheimer's disease (AD). We show that in an aged transgenic AD mouse model …

Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …

The serotonergic system is implicated in the neurobiological control of learning and memory,
both in healthy individuals and pathological disorders, although the underlying mechanisms …

The amyloid cascade hypothesis is the most accepted explanation for the pathogenesis of
Alzheimer's disease (AD). APP is the precursor of the amyloid β peptide (Aβ), the principal …