Modeling type 2 diabetes in rats using high fat diet and streptozotocin

S Skovsø - Journal of diabetes investigation, 2014 - Wiley Online Library
The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …

Structural features and biological activities of the polysaccharides from Astragalus membranaceus

M Jin, K Zhao, Q Huang, P Shang - International Journal of Biological …, 2014 - Elsevier
Recently, a great deal of interest has been developed to isolate and investigate novel
bioactive components with health benefit effects from natural resources. The dried root of …

Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice

Y Hong, L Sheng, J Zhong, X Tao, W Zhu, J Ma… - Gut …, 2021 - Taylor & Francis
The emerging evidence supports the use of prebiotics like herb-derived polysaccharides for
treating nonalcoholic fatty liver disease (NAFLD) by modulating gut microbiome. The present …

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

W Xie, L Du - Diabetes, obesity and metabolism, 2011 - Wiley Online Library
Diabetes is usually associated with inflammation. Inflammation contributes to the
development of diabetes. Traditional Chinese medicines (TCM) play an important role in …

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

Z Guo, Y Lou, M Kong, Q Luo, Z Liu, J Wu - International journal of …, 2019 - mdpi.com
Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines.
Modern pharmacological studies and clinical practices indicate that AR possesses various …

System pharmacology-based dissection of the synergistic mechanism of Huangqi and Huanglian for diabetes mellitus

SJ Yue, J Liu, WW Feng, FL Zhang, JX Chen… - Frontiers in …, 2017 - frontiersin.org
The rapidly increasing diabetes mellitus (DM) is becoming a major global public health
issue. Traditional Chinese medicine (TCM) has a long history of the treatment of DM with …

Recent advances in medicinal and edible homologous plant polysaccharides: Preparation, structure and prevention and treatment of diabetes

L Li, J Xie, Z Zhang, B Xia, Y Li, Y Lin, M Li… - International journal of …, 2024 - Elsevier
Medicinal and edible homologs (MEHs) can be used in medicine and food. The National
Health Commission announced that a total of 103 kinds of medicinal and edible …

Pharmacological effects and molecular protective mechanisms of Astragalus polysaccharides on nonalcoholic fatty liver disease

J Zhang, Q Feng - Frontiers in pharmacology, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) has been renamed metabolic dysfunction-
associated fatty liver disease (MAFLD), a condition for which there is now no authorized …

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice

Q Song, SW Cheng, D Li, H Cheng, YS Lai… - Frontiers in …, 2022 - frontiersin.org
Gut microbiota has been reported to be closely associated with Type-II diabetes. Restoration
of disordered gut microbiota ecosystem has been developed into a therapeutic strategy and …

Astragalus species: Insights on its chemical composition toward pharmacological applications

B Salehi, JNP Carneiro, JE Rocha… - Phytotherapy …, 2021 - Wiley Online Library
Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and
North America. The genus is widely used in folk medicine and in dietary supplements, as …