The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …

New developments in the program package ATSAS (version 2.4) for the processing and
analysis of isotropic small-angle X-ray and neutron scattering data are described. They …

Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

Cancer is a major cause of death worldwide. MET tyrosine kinase receptor [MET, c-MET,
hepatocyte growth factor (HGF) receptor] pathway activation is associated with the …

Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways
that mediate cell-to-cell communication. These single-pass transmembrane receptors, which …

Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET
cellular proto-oncogene, are expressed in the nervous system from pre-natal development …

Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …

The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …