Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

To facilitate the process of aging healthily and prevent age-related health problems, efforts
to properly understand aging mechanisms and develop effective and affordable anti-aging …

Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of
disability and loss of independence. High intensity interval training (HIIT) may provide a …

Aging is a natural biological event that has some downsides such as increased frailty,
decline in cognitive and physical functions leading to chronical diseases, and lower quality …

Frailty is a state of high vulnerability to adverse health outcomes. This concept is used to
explain the heterogeneity in rates of aging in people of the same age. Frailty has important …

Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …

Age is the most important risk factor for Alzheimer's disease (AD). The acceptable age range
for participation in AD clinical trials is 50 to 90, and this 40-year span incorporates enormous …

Although frailty has been extensively investigated for the last 2 decades, preclinical models
of frailty have only been developed over the past decade. Frailty is a concept that helps to …

Frailty is a clinical geriatric syndrome characterized by decreased multisystem function and
increased vulnerability to adverse outcomes. Although numerous studies have been …

The underlying mechanisms contributing to the onset of frailty, its progression, and its
mortality risk remain unknown. Recently, the two most common human frailty assessments …