Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology and target identification and in the evaluation of novel …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because
of the limited availability of appropriate samples, but we now report a detailed study charting …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Starting with early crucial discoveries of the role of the major histocompatibility complex,
genetic studies have long had a role in understanding the biology of type 1 diabetes (T1D) …

NIDDK, JDRF, and the Diabetic Neuropathy Study Group of EASD sponsored a meeting to
explore the current status of animal models of diabetic peripheral neuropathy. The goal of …

Inbred mouse strains provide genetic diversity comparable to that of the human population.
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …

Background Non‐obese diabetic (NOD) mice are regarded as being excellent animal
models of human type 1 diabetes or insulin dependent diabetes (IDDM). This study …

Diabetic neuropathy, also called peripheral diabetic neuropathy (PDN), is among the most
significant diabetes health consequences, alongside diabetic nephropathy, diabetic …

Objective: The need of today's research is to develop successful and reliable diabetic animal
models for understanding the disease susceptibility and pathogenesis. Enormous success …