Advances in the management of Acanthamoeba keratitis: a review of the literature and synthesized algorithmic approach

AR Kaufman, EY Tu - The Ocular Surface, 2022 - Elsevier
Acanthamoeba keratitis (AK) is a severe cause of infectious keratitis and represents a
significant clinical challenge. Recent literature regarding AK epidemiology, diagnosis …

Therapeutic agents and biocides for ocular infections by free-living amoebae of Acanthamoeba genus

LC Carrijo-Carvalho, VP Sant'ana, AS Foronda… - survey of …, 2017 - Elsevier
Acanthamoeba keratitis is a sight-threatening infectious disease. Resistance of the cystic
form of the protozoan to biocides and the potential toxicity of chemical compounds to corneal …

[PDF][PDF] Acanthamoeba

NA Khan - Biology and pathogenesis, 2009 - caister.com
1. A host for viruses 2. A host for yeast 3. A host for protists 4. Acanthamoeba and bacteria
interactions 5. Is Acanthamoebaan evolutionary ancestor of macrophages? 6 …

Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii

CM Martín-Navarro, A López-Arencibia… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Members of the genus Acanthamoeba are facultative pathogens of humans, causing a sight-
threatening keratitis and a life-threatening encephalitis. In order to treat those infections …

[HTML][HTML] Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

S Thomson, CA Rice, T Zhang, RA Edrada-Ebel… - Scientific reports, 2017 - nature.com
The soil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-
threatening infection of the eye and the almost universally fatal granulomatous amoebic …

Brain-eating amoebae infection: Challenges and opportunities in chemotherapy

MR Mungroo, A Anwar, NA Khan… - Mini reviews in …, 2019 - ingentaconnect.com
Pathogenic free-living amoeba are known to cause a devastating infection of the central
nervous system and are often referred to as “brain-eating amoebae”. The mortality rate of …

Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case

A González-Robles, L Salazar-Villatoro… - Journal of …, 2014 - Wiley Online Library
Light and transmission electron microscopy observations are reported on the structure and
in vitro cytopathic effect of Acanthamoeba griffini trophozoites isolated from a clinical case …

A randomized masked pilot clinical trial to compare the efficacy of topical 1% voriconazole ophthalmic solution as monotherapy with combination therapy of topical …

B Bagga, S Sharma, RPS Gour, A Mohamed, J Joseph… - Eye, 2021 - nature.com
Purpose To compare the efficacy of topical voriconazole 1% and the combination therapy of
0.02% polyhexamethylene biguanide (PHMB) and 0.02% chlorhexidine for the treatment of …

[HTML][HTML] Voriconazole in the successful management of a case of Acanthamoeba-Cladosporium keratitis

A Raghavan, AV Nair, N Kavitha… - American Journal of …, 2021 - Elsevier
Purpose Acanthamoeba and fungal infections can be recalcitrant to therapy-more so when
the deeper layers of the corneas are involved. We describe the diagnosis and successful …

Cysticidal activity of antifungals against different genotypes of Acanthamoeba

A Iovieno, D Miller, DR Ledee… - Antimicrobial agents and …, 2014 - Am Soc Microbiol
Antifungal drugs have been proposed as a novel treatment for Acanthamoeba keratitis. The
cysticidal activity of several antifungal compounds was tested against different genotypes of …