Mechanisms and clinical importance of bacteriophage resistance

JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …

[HTML][HTML] Phage therapy in the resistance era: where do we stand and where are we going?

T Luong, AC Salabarria, DR Roach - Clinical therapeutics, 2020 - Elsevier
Purpose Widespread antibiotic-resistant bacteria are threatening the arsenal of existing
antibiotics. Not only are antibiotics less likely to be effective today, but their extensive use …

Assessment of course-based undergraduate research experiences: a meeting report

LC Auchincloss, SL Laursen, JL Branchaw, K Eagan… - 2014 - Am Soc Cell Biol
The Course-Based Undergraduate Research Experiences Network (CUREnet) was initiated
in 2012 with funding from the National Science Foundation program for Research …

A broadly implementable research course in phage discovery and genomics for first-year undergraduate students

TC Jordan, SH Burnett, S Carson, SM Caruso, K Clase… - MBio, 2014 - Am Soc Microbiol
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but
difficult to achieve. We have developed a general model in which faculty and teaching …

Actinobacteriophages: genomics, dynamics, and applications

GF Hatfull - Annual review of virology, 2020 - annualreviews.org
Actinobacteriophages are viruses that infect bacterial hosts in the phylum Actinobacteria.
More than 17,000 actinobacteriophages have been described and over 3,000 complete …

Mycobacteriophages: from petri dish to patient

GF Hatfull - PLoS Pathogens, 2022 - journals.plos.org
Mycobacteriophages—bacteriophages infecting Mycobacterium hosts—contribute
substantially to our understanding of viral diversity and evolution, provide resources for …

Bacteriophages and their genomes

GF Hatfull, RW Hendrix - Current opinion in virology, 2011 - Elsevier
Bacteriophages occupy a unique position in biology, representing an absolute majority of all
organisms in the biosphere. Because their genomes are relatively small, elucidating the …

Phamerator: a bioinformatic tool for comparative bacteriophage genomics

SG Cresawn, M Bogel, N Day, D Jacobs-Sera… - BMC …, 2011 - Springer
Background Bacteriophage genomes have mosaic architectures and are replete with small
open reading frames of unknown function, presenting challenges in their annotation …

Evolutionary ecology of prokaryotic immune mechanisms

S van Houte, A Buckling, ER Westra - Microbiology and Molecular …, 2016 - Am Soc Microbiol
Bacteria have a range of distinct immune strategies that provide protection against
bacteriophage (phage) infections. While much has been learned about the mechanism of …

Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

WH Pope, CA Bowman, DA Russell, D Jacobs-Sera… - elife, 2015 - elifesciences.org
The bacteriophage population is large, dynamic, ancient, and genetically diverse. Limited
genomic information shows that phage genomes are mosaic, and the genetic architecture of …