Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase …

S Khan, H Ullah, R Hussain, Y Khan, MU Khan… - Journal of Molecular …, 2023 - Elsevier
Analogues of isatin/bis-Schiff bases based on thiocarbohydrazone (1–16) were synthesized,
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …

Design, synthesis, spectroscopic characterization, single crystal X-ray analysis, in vitro α-amylase inhibition assay, DPPH free radical evaluation and computational …

M Devi, P Kumar, R Singh, J Sindhu… - European Journal of …, 2023 - Elsevier
In our quest to design and develop N/O-containing inhibitors of α-amylase, we have tried to
synergize the inhibitory action of 1, 4-naphthoquinone, imidazole and 1, 2, 3-triazole motifs …

CORAL: probing the structural requirements for α-amylase inhibition activity of 5-(3-arylallylidene)-2-(arylimino) thiazolidin-4-one derivatives based on QSAR with …

R Singh, P Kumar, J Sindhu, A Kumar… - Journal of Biomolecular …, 2023 - Taylor & Francis
The present study aims to examine the structural requirements governing α-amylase
inhibitory activity of 5-(3-arylallylidene)-2-(arylimino) thiazolidin-4-one derivatives and their …

α‐Amylase Inhibitors Based on Thiazolidinone Skeleton: A Promising Approach in Diabetes Management

R Singh, J Sindhu, P Kumar, M Hooda… - …, 2023 - Wiley Online Library
Thiazolidinone scaffold has become a promising scaffold when it comes to therapeutic
importance, and researchers are quite interested in it because of its wide range of …

Mechanism and stereoselectivity of epoxidation reaction of a β-himachalene derivative: Insights from DFT, molecular docking, ADMET, and molecular dynamics …

B Rossafi, F Outahar, I Hammoudan, M Moumou… - Journal of Molecular …, 2025 - Elsevier
Epoxidation of a β-himachalene derivative (A) can be carried out using meta-
chloroperoxybenzoic acid (m-CPBA). An oxygen atom is added to the double bond C 9 …

Targeting α-amylase enzyme through multi-fold structure-based virtual screening and molecular dynamic simulation

SA Halim, HW Lodhi, M Waqas, A Khalid… - Journal of …, 2024 - Taylor & Francis
Abstract α-Amylase play important role in hydrolyses of α-bonds of large α-linked
polysaccharides; thus, it is a potential drug target in diabetes mellites (DM) and its inhibition …

Synthesis, CN/NN Bond Conformational Analysis and Evaluation of Naphtho [2, 3-d][1, 2, 3] triazole-4, 9-dione tethered N-acyl Hydrazones as α-Amylase Inhibitors …

M Devi, J Sindhu, R Singh, S Lal, A Kumar… - Journal of Molecular …, 2024 - Elsevier
In an effort to expand the repertoire of potent α-amylase inhibitors, we sought to enhance the
inhibitory potential by combining 1, 4-naphthoquinone, 1, 2, 3-triazole, and N-acyl …

One-pot domino synthesis of 1H-isochromene and pyran carbonitrile from pyrazole aldehyde derivatives as potential anti-diabetic and antioxidant targets

P Monisha, S Amalraj, P Gangapriya, S Prabhu… - Journal of Molecular …, 2024 - Elsevier
The compounds, 1H-Isochromene and pyran carbonitrile were synthesized from the
pyrazole aldehyde derivatives through efficient synthetic routes and characterization was …

[HTML][HTML] Anti-Diabetic, Anti-Cholinesterase, and Anti-Inflammatory Potential of Plant Derived Extracts and Column Semi-Purified Fractions of Ficus benghalensis

A Rauf, N Almasoud, M Ibrahim, TS Alomar… - Frontiers in Bioscience …, 2024 - imrpress.com
Background: The present study aimed to investigate the in-vitro anti-diabetic, anti-
cholinesterase, and anti-inflammatory potential of extracts from different parts of Ficus …

Análisis teórico de planta antidiabética del Género Justicia: valiosa fuente de inhibidores α-glucosidasa

LP Beltrán Jakes - 2024 - repositorio.uas.edu.mx
Esta investigación se enfoca en la búsqueda y caracterización de extractos de las plantas
medicinales del género Justicia. Para llevar a cabo esta investigación, se emplearon …