Mechanical forces collaborate across length scales to coordinate cell fate during
development and the dynamic homeostasis of adult tissues. Similarly, steroid hormones …

Harnessing the differences between cancer and non-cancer tissues presents new
opportunities for selective targeting by anti-cancer drugs. CD13, a heavily glycosylated …

Malignant tumors are a category of diseases that possess invasive and metastatic
capabilities, with global incidence and mortality rates remaining high. In recent years, the …

Brain metastatic breast cancer is particularly lethal largely due to therapeutic resistance.
Almost half of the patients with metastatic HER2-positive breast cancer develop brain …

Abstract Objectives PD‐1/PD‐L1 immune checkpoint blockade can be an effective treatment
for advanced breast cancer patients. However, patients with oestrogen receptor positive …

Since the role of sialome–Siglec axis has been described as a regulatory checkpoint of
immune homeostasis, the promotion of stimulatory or inhibitory Siglec-related mechanisms …

Although in early days the glycocalyx was assumed to simply provide a protective coating for
cells, work over the last several decades has revealed the glycocalyx to be an intricate and …

Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are
built with in vitro models that do not match the microenvironmental characteristics of human …

Hypersialylation is a prognostic biomarker in cancer cells. The upregulated sialic acid
expression on cancer cells facilitates tumorigenesis by playing a critical role in cancer cell …

Testicular germ cell tumour (TGCT) is a malignancy that mainly affects young men of
reproductive age. Cryopreservation of sperm prior to cancer treatment often represents the …