RNAs have emerged as a major target for diagnostics and therapeutics approaches. Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Abstract Tautomeric and anionic Watson–Crick-like mismatches have important roles in replication and translation errors through mechanisms that are not fully understood. Here …
The B-DNA double helix can dynamically accommodate GC and AT base pairs in either Watson–Crick or Hoogsteen configurations. Here, we show that G-C+ (in which+ indicates …
AG Palmer III, H Koss - Methods in enzymology, 2019 - Elsevier
The phenomenon of chemical or conformational exchange in NMR spectroscopy has enabled detailed characterization of time-dependent aspects of biomolecular function …
This review describes off-resonance R 1ρ relaxation dispersion NMR methods for characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
H Shi, B Liu, F Nussbaumer… - Journal of the …, 2019 - ACS Publications
N 6-Methyladenosine (m6A) is an abundant epitranscriptomic modification that plays important roles in many aspects of RNA metabolism. While m6A is thought to mainly function …
AN Jones, M Sattler - Journal of Molecular Cell Biology, 2019 - academic.oup.com
Following the discovery of numerous long non-coding RNA (lncRNA) transcripts in the human genome, their important roles in biology and human disease are emerging. Recent …
In the canonical DNA double helix, Watson–Crick (WC) base pairs (bps) exist in dynamic equilibrium with sparsely populated (∼ 0.02–0.4%) and short-lived (lifetimes∼ 0.2–2.5 ms) …
Aromatic residues are located at structurally important sites of many proteins. Probing their interactions and dynamics can provide important functional insight but is challenging in …