Insights into the regulatory role of bacterial sncRNA and its extracellular delivery via OMVs

M He, S Yin, X Huang, Y Li, B Li, T Gong… - Applied Microbiology and …, 2024 - Springer
Small noncoding RNAs (sncRNAs) play important regulatory roles in bacterial physiological
processes and host-pathogen interactions. Meanwhile, bacterial outer membrane vesicles …

Airway environment drives the selection of quorum sensing mutants and promote Staphylococcus aureus chronic lifestyle

X Ding, C Robbe-Masselot, X Fu, R Léonard… - Nature …, 2023 - nature.com
Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway
environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is …

Exploring the targetome of IsrR, an iron-regulated sRNA controlling the synthesis of iron-containing proteins in Staphylococcus aureus

A Ganske, LM Busch, C Hentschker, A Reder… - Frontiers in …, 2024 - frontiersin.org
Staphylococcus aureus is a common colonizer of the skin and nares of healthy individuals,
but also a major cause of severe human infections. During interaction with the host …

Coordinated adaptation of Staphylococcus aureus to calprotectin-dependent metal sequestration

VM Reyes Ruiz, JA Freiberg, A Weiss, ER Green… - Mbio, 2024 - journals.asm.org
The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through
metal sequestration in a process known as “nutritional immunity.” Staphylococcus aureus …

Fpa (YlaN) is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus

JM Boyd, K Ryan Kaler, K Esquilín-Lebrón, A Pall… - Mbio, 2024 - journals.asm.org
Iron (Fe) is a trace nutrient required by nearly all organisms. As a result of the demand for Fe
and the toxicity of non-chelated cytosolic ionic Fe, regulatory systems have evolved to tightly …

Staphylococcal sRNA IsrR downregulates methylthiotransferase MiaB under iron-deficient conditions

M Barrault, E Leclair, EK Kumeko, E Jacquet… - Microbiology …, 2024 - journals.asm.org
Staphylococcus aureus is a major contributor to bacterial-associated mortality, owing to its
exceptional adaptability across diverse environments. Iron is vital to most organisms but can …

The Staphylococcus aureus non-coding RNA IsrR regulates TCA cycle activity and virulence

G Rios-Delgado, AKG McReynolds… - Nucleic Acids …, 2024 - academic.oup.com
Staphylococcus aureus has evolved mechanisms to cope with low iron (Fe) availability in
host tissues. Staphylococcus aureus uses the ferric uptake transcriptional regulator (Fur) to …

Staphylococcal aconitase expression during iron deficiency is controlled by an sRNA-driven feedforward loop and moonlighting activity

M Barrault, S Chabelskaya… - Nucleic Acids …, 2024 - academic.oup.com
Pathogenic bacteria employ complex systems to cope with metal ion shortage conditions
and propagate in the host. IsrR is a regulatory RNA (sRNA) whose activity is decisive for …

The small RNA PrrH of Pseudomonas aeruginosa regulates hemolysis and oxidative resistance in bloodstream infection

S Zeng, Q Shi, YZ Liu, M Li, D Lin, S Zhang, Q Li… - Microbial …, 2023 - Elsevier
Small regulatory RNAs (sRNAs) regulate multiple physiological functions in bacteria, and
sRNA PrrH can regulate iron homeostasis and virulence. However, the function of PrrH in …

Comprehensive Genomics and Proteomics Analysis Reveals the Multiple Response Strategies of Endophytic Bacillus sp. WR13 to Iron Limitation

Z Yue, Y Liu, Y Chen, C Chen, J Zhang, L He, K Ma - Microorganisms, 2023 - mdpi.com
Iron (Fe) is an important metal element for the growth of bacteria. Many bacteria respond to
Fe limitation through a variety of strategies. We previously isolated an endophyte Bacillus …