Siderophores in iron metabolism: from mechanism to therapy potential

BR Wilson, AR Bogdan, M Miyazawa… - Trends in molecular …, 2016 - cell.com
Iron is an essential nutrient for life. During infection, a fierce battle of iron acquisition occurs
between the host and bacterial pathogens. Bacteria acquire iron by secreting siderophores …

[HTML][HTML] Mitophagy and innate immunity in infection

DH Cho, JK Kim, EK Jo - Molecules and cells, 2020 - Elsevier
Mitochondria have several quality control mechanisms by which they maintain cellular
homeostasis and ensure that the molecular machinery is protected from stress. Mitophagy …

The multifaceted regulation of mitophagy by endogenous metabolites

T Zhang, Q Liu, W Gao, SA Sehgal, H Wu - Autophagy, 2022 - Taylor & Francis
Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …

Ubiquitin and receptor-dependent mitophagy pathways and their implication in neurodegeneration

LE Fritsch, ME Moore, SA Sarraf, AM Pickrell - Journal of molecular biology, 2020 - Elsevier
Selective autophagy of mitochondria, or mitophagy, refers to the specific removal and
degradation of damaged or surplus mitochondria via targeting to the lysosome for …

Mitochondrial mechanisms in Alzheimer's disease: Quest for therapeutics

K Kalani, P Chaturvedi, P Chaturvedi, VK Verma… - Drug Discovery …, 2023 - Elsevier
Highlights•Mitochondria decide the progression of Alzheimer's disease.•AD pathology and
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …

Mitochondrial clearance: mechanisms and roles in cellular fitness

M Onishi, K Okamoto - FEBS letters, 2021 - Wiley Online Library
Mitophagy is one of the selective autophagy pathways that catabolizes dysfunctional or
superfluous mitochondria. Under mitophagy‐inducing conditions, mitochondria are labeled …

[HTML][HTML] Adaptation to iron deficiency in human pathogenic fungi

MT Martínez-Pastor, S Puig - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Iron is an essential micronutrient for virtually all eukaryotic organisms and plays a central
role during microbial infections. Invasive fungal diseases are associated with strikingly high …

[HTML][HTML] Phosphatidylinositol 3-phosphate regulates iron transport via PI3P-binding CgPil1 protein

F Askari, B Vasavi, R Kaur - Cell Reports, 2023 - cell.com
Iron homeostasis, which is pivotal to virulence, is regulated by the phosphatidylinositol 3-
kinase CgVps34 in the human fungal pathogen Candida glabrata. Here, we identify CgPil1 …

[HTML][HTML] Iron chelators as mitophagy agents: Potential and limitations

T Brogyanyi, Z Kejík, K Veselá, P Dytrych… - Biomedicine & …, 2024 - Elsevier
Mitochondrial autophagy (mitophagy) is very important process for the maintenance of
cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk …

[PDF][PDF] Iron deficiency-induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria-containing …

PA Leermakers, AHV Remels, MI Zonneveld… - 2020 - repository.ubn.ru.nl
Iron homeostasis is essential for mitochondrial function, and iron deficiency has been
associated with skeletal muscle weakness and decreased exercise capacity in patients with …