Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Cholinesterase reactivators and bioscavengers for pre‐and post‐exposure treatments of organophosphorus poisoning

P Masson, F Nachon - Journal of neurochemistry, 2017 - Wiley Online Library
Organophosphorus agents (OP s) irreversibly inhibit acetylcholinesterase (AC hE) causing a
major cholinergic syndrome. The medical counter‐measures of OP poisoning have not …

Improving protein quantity and quality—The next level of plant molecular farming

H Liu, MP Timko - International Journal of Molecular Sciences, 2022 - mdpi.com
Plants offer several unique advantages in the production of recombinant pharmaceuticals for
humans and animals. Although numerous recombinant proteins have been expressed in …

The advent of plant cells in bioreactors

F Verdú-Navarro, JA Moreno-Cid, J Weiss… - Frontiers in Plant …, 2023 - frontiersin.org
Ever since agriculture started, plants have been bred to obtain better yields, better fruits, or
sustainable products under uncertain biotic and abiotic conditions. However, a new way to …

Techno‐economic analysis of a plant‐based platform for manufacturing antimicrobial proteins for food safety

MJ McNulty, Y Gleba, D Tusé… - Biotechnology …, 2020 - Wiley Online Library
Continuous reports of foodborne illnesses worldwide and the prevalence of antibiotic‐
resistant bacteria mandate novel interventions to assure the safety of our food. Treatment of …

Human protein paucimannosylation: cues from the eukaryotic kingdoms

HC Tjondro, I Loke, S Chatterjee… - Biological …, 2019 - Wiley Online Library
Paucimannosidic proteins (PMPs) are bioactive glycoproteins carrying truncated α‐or β‐
mannosyl‐terminating asparagine (N)‐linked glycans widely reported across the eukaryotic …

RNA silencing suppressor-influenced performance of a virus vector delivering both guide RNA and Cas9 for CRISPR gene editing

KT Chiong, WB Cody, HB Scholthof - Scientific Reports, 2021 - nature.com
We report on further development of the agroinfiltratable Tobacco mosaic virus (TMV)-based
overexpression (TRBO) vector to deliver CRISPR/Cas9 components into plants. First …

Current approaches to enhancing oxime reactivator delivery into the brain

T Kobrlova, J Korabecny, O Soukup - Toxicology, 2019 - Elsevier
The misuse of organophosphate compounds still represents a current threat worldwide.
Treatment of poisoning with organophosphates (OPs) remains unsatisfactorily resolved …

Technoeconomic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures

JM Corbin, MJ McNulty, K Macharoen… - Biotechnology and …, 2020 - Wiley Online Library
Biopharmaceutical protein production using transgenic plant cell bioreactor processes offers
advantages over microbial and mammalian cell culture platforms in its ability to produce …

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

MR Leung, LS van Bezouwen… - Proceedings of the …, 2018 - National Acad Sciences
The quaternary structures of the cholinesterases, acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), are essential for their localization and function. Of practical …