Nanosizing is one of the most important drug delivery platform approaches for the
commercial development of poorly soluble drug molecules. The research efforts of many …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

The aim of this tutorial is to introduce the fundamental concepts of physiologically based
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …

Abstract The Biopharmaceutics Classification System (BCS) has found widespread utility in
drug discovery, product development and drug product regulatory sciences. The …

Physiologically based pharmacokinetic (PBPK) modeling and physiologically based
biopharmaceutics modeling (PBBM) are invaluable tools with wide applications during drug …

Cellular metabolism continuously processes an enormous range of external compounds into
endogenous metabolites and is as such a key element in human physiology. The …

The delivery of therapeutic agents is characterized by numerous challenges including poor
absorption, low penetration in target tissues and non‐specific dissemination in organs …

Abstract To implement Quality by Design (QbD) in drug development, scientists need tools
that link drug products properties to in vivo performance. Physiologically based absorption …

Orally administered drugs are subject to a number of barriers impacting bioavailability (F
oral), causing challenges during drug and formulation development. Physiologically-based …

The present work evaluates the food effect on the absorption of rivaroxaban (Riva), a BCS II
drug, from the orally administered commercial immediate-release tablet (Xarelto IR) using …