Bioactive inorganic nanomaterials for cancer theranostics

Z Pei, H Lei, L Cheng - Chemical Society Reviews, 2023 - pubs.rsc.org
Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

Copper-based metal–organic frameworks for biomedical applications

JE Cun, X Fan, Q Pan, W Gao, K Luo, B He… - Advances in Colloid and …, 2022 - Elsevier
Metal–organic frameworks (MOFs) are a class of important porous, crystalline materials
composed of metal ions (clusters) and organic ligands. Owing to the unique redox chemistry …

An injectable and active hydrogel induces mutually enhanced mild magnetic hyperthermia and ferroptosis

X Chen, H Wang, J Shi, Z Chen, Y Wang, S Gu, Y Fu… - Biomaterials, 2023 - Elsevier
Magnetic hyperthermia therapy (MHT) is a promising new modality to deal with solid tumors,
yet the low magnetic-heat conversion efficacy, magnetic resonance imaging (MRI) artifacts …

Blocking glutathione regeneration: inorganic NADPH oxidase nanozyme catalyst potentiates tumoral ferroptosis

C Wu, D Xu, M Ge, J Luo, L Chen, Z Chen, Y You… - Nano Today, 2022 - Elsevier
Emerging cancer cell ferroptosis features the direct depletion of glutathione (GSH) and
resultant chemical inhibition on glutathione peroxidase 4 (GPX4) bioactivity, which …

Specific activation of cGAS-STING pathway by nanotherapeutics-mediated ferroptosis evoked endogenous signaling for boosting systemic tumor immunotherapy

JL Liang, XK Jin, SM Zhang, QX Huang, P Ji, XC Deng… - Science Bulletin, 2023 - Elsevier
Activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING)
pathway could effectively initiate antitumor immunity, but specific activation of STING …

A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity

Y Zhang, X Du, Z He, S Gao, L Ye, J Ji, X Yang… - ACS nano, 2023 - ACS Publications
Ferroptosis activation has been considered a mighty weapon for cancer treatment, and
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …

All-in-one engineering multifunctional nanoplatforms for sensitizing tumor low-temperature photothermal therapy in vivo

K Li, K Xu, S Liu, Y He, M Tan, Y Mao, Y Yang, J Wu… - ACS …, 2023 - ACS Publications
Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the
photothermal effect at low temperatures to selectively eliminate tumor cells, while …

Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment

Z He, H Zhou, Y Zhang, X Du, S Liu, J Ji, X Yang… - Biomaterials, 2022 - Elsevier
Photodynamic therapy (PDT) induces apoptosis of cancer cells by generating cytotoxic
reactive oxygen species, the therapeutic effect of which, however, is impeded by …

[HTML][HTML] Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets

Y Wang, Z Zhang, W Sun, J Zhang, Q Xu, X Zhou… - Biomedicine & …, 2022 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor characterized by unchecked division
and survival of abnormal cells in the colon or rectum with high morbidity and mortality …

Clustered cobalt nanodots initiate ferroptosis by upregulating heme oxygenase 1 for radiotherapy sensitization

J Zhao, Y Chen, T Xiong, S Han, C Li, Y He, Y He… - Small, 2023 - Wiley Online Library
High cobalt (Co) levels in tumors are associated with good clinical prognosis. An anticancer
regimen that increases intratumoral Co through targeted nanomaterial delivery is proposed …