Are “mystical experiences” essential for antidepressant actions of ketamine and the classic psychedelics?

K Hashimoto - European Archives of Psychiatry and Clinical …, 2024 - Springer
The growing interest in the rapid and sustained antidepressant effects of the dissociative
anesthetic ketamine and classic psychedelics, such as psilocybin, is remarkable. However …

[HTML][HTML] The mechanistic divide in psychedelic neuroscience: An unbridgeable gap?

BR Barksdale, MK Doss, GA Fonzo, CB Nemeroff - Neurotherapeutics, 2024 - Elsevier
In recent years, psychedelics have generated considerable excitement and interest as
potential novel therapeutics for an array of conditions, with the most advanced evidence …

Assessing potential of psilocybin for depressive disorders

Z Kozak, MW Johnson, ST Aaronson - Expert Opinion on …, 2023 - Taylor & Francis
Introduction There has been increasing interest in the role psilocybin may play in the
treatment of depressive disorders. Several clinical trials have shown psilocybin to have …

Psychedelics as an intervention for psychological, existential distress in terminally ill patients: A systematic review and network meta-analysis

M Marchi, R Farina, K Rachedi… - Journal of …, 2024 - journals.sagepub.com
Background: The interest in psychedelics as a therapeutic intervention for existential distress
of people with terminal illness grounds on their mechanism of action and effect on the …

Psilocybin: from psychiatric pariah to perceived panacea

GA Fonzo, AS Wolfgang, BR Barksdale… - American Journal of …, 2025 - psychiatryonline.org
Objective: The authors critically examine the evidence base for psilocybin administered with
psychological support/therapy (PST) in the treatment of psychiatric disorders and offer …

[HTML][HTML] Comparison between Single-Dose and Two-Dose Psilocybin Administration in the Treatment of Major Depression: A Systematic Review and Meta-Analysis of …

G Salvetti, D Saccenti, AS Moro, J Lamanna, M Ferro - Brain Sciences, 2024 - mdpi.com
Current pharmacological treatments for major depressive disorder (MDD) are often only
partially effective, with many patients experiencing no significant benefit, leading to …

Preferences, Perceptions, and Environmental Considerations of Natural and Synthetic Psychedelic Substances: Findings from the Global Psychedelic Survey

OA Syed, R Petranker, EC Fewster… - Journal of …, 2024 - Taylor & Francis
Although several studies have well described the characteristics of people who use
psychedelics alongside their motivations and beliefs, little research has examined the …

Neural effects of psychedelics: Complexity the key word

BDM Jones, MI Husain - Neuropsychopharmacology, 2024 - nature.com
It is impossible to ignore the rapidly growing interest in the therapeutic use of psychedelics.
Once marginalized as elements of counterculture, substances such as lysergic acid …

Review of Psilocybin Use for Depression among Cancer Patients after Approval in Oregon

V Bellman - Cancers, 2024 - mdpi.com
Simple Summary Psilocybin therapy shows promise for reducing anxiety and depression
and improving psychological well-being in cancer patients nearing the end of life. However …

Recent advances in the synthesis of antidepressant derivatives: pharmacologic insights for mood disorders

JK Gupta, K Singh, A Bhatt, P Porwal, R Rani, A Dubey… - 3 Biotech, 2024 - Springer
Mood disorders, including depression, remain a significant global health concern,
necessitating continuous efforts to develop novel and more effective antidepressant …