Synthetic organic electrosynthesis has grown in the past few decades by achieving many
valuable transformations for synthetic chemists. Although electrocatalysis has been popular …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

The ability to selectively introduce diverse functionality onto hydrocarbons is of substantial
value in the synthesis of both small molecules and polymers. Herein, we report an approach …

The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

The polarity of a radical intermediate profoundly impacts its reactivity and selectivity. To
quantify this influence and predict its effects, the electrophilicity/nucleophilicity of> 500 …

Chlorine radicals readily activate C–H bonds, but the high reactivity of these intermediates
precludes their use in regioselective C–H functionalization reactions. We demonstrate that …

The adoption of a supramolecular approach in catalysis promises to address a number of
unmet challenges, ranging from activity (unlocking of novel reaction pathways) to selectivity …

The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …

The current status of homogeneous iron catalysis in organic chemistry is contemplated, as
are the reasons why this particular research area only recently starts challenging the …

The present review “Iron Catalysis in Organic Synthesis” covers the literature until the end of
June 2014 and represents a comprehensive update of a previous article published by Bolm …