Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …

It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is
dysregulated in various cancers, and its upregulation strongly correlates with an invasive …

Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous
cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding …

Background B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) acts as
an oncogene in various tumors, and its overexpression correlates with a poor outcome in …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are
responsible for tumor regrowth and disease relapse. Bmi‐1 plays a critical role in the self …