DNA methylation is one of the significant epigenetic modifications involved in mammalian
development as well as in the initiation and progression of various diseases like cancer …

DNA methylation is a key factor in the pathogenesis of gene expression diseases or
malignancies. Thus, it has become a significant biomarker for the diagnosis and prognosis …

Nanomaterials (nanozymes) with peroxidase-mimetic activity have been widely used in
biosensing platforms as low-cost, relatively stable and prevailing alternatives to natural …

Early detection and effective treatment are crucial to reduce the physical, emotional, and
financial pressure exerted by growing cancer burden on individuals, families, communities …

Biomarkers based on DNA methylation have attracted wide attention in biomedical research
due to their potential clinical value. Therefore, a sensitive and accurate method for DNA …

DNA methylation is considered to be a promising marker for the early diagnosis and
prognosis of cancer. However, direct detection of the methylated DNAs in clinically relevant …

Affinity assays allow direct detection of DNA methylation events without requiring a special
sequence. However, the signal amplification of these methods heavily depends on …

In this paper we report on a bisulfite treatment and PCR amplification-free method for
sensitive and selective quantifying of global DNA methylation. Our method utilizes a three …

Biomolecules like cysteine and cytosine play a significant role in many physiological
processes, and their unusual level in biological systems can lead to many diseases …

Aberrant DNA methylation plays a pivotal role in tumor development and metastasis, and is
regarded as a valuable non-invasive cancer biomarker. However, the sensitive and accurate …