The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …

After induction and specification in the ectoderm, at the border of the neural plate, the neural
crest (NC) population leaves its original territory through a delamination process. Soon …

The earliest aspects of human embryogenesis remain mysterious. To model patterning
events in the human embryo, we used colonies of human embryonic stem cells (hESCs) …

Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …

Delamination of premigratory neural crest cells depends on a balance between BMP/noggin
and on successful G1/S transition. Here, we report that BMP regulates G1/S transition and …

During neural crest ontogeny, an epithelial to mesenchymal transition is necessary for cell
emigration from the dorsal neural tube. This process is likely to involve a network of gene …

Colonization of trunk neural crest derivatives in avians follows a ventral to dorsal order
beginning with sympathetic ganglia, Schwann cells, sensory ganglia and finally …

Dorsolateral bending of the neural plate, an undifferentiated pseudostratified epithelium, is
essential for neural tube closure in the mouse spinal region. If dorsolateral bending fails …

Development requires the careful orchestration of several biological events in order to
create any structure and, eventually, to build an entire organism. On the other hand, the fate …

Delamination of premigratory neural crest cells from the dorsal neural tube depends both
upon environmental signals and cell-intrinsic mechanisms and is a prerequisite for cells to …