Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Conspectus Despite tremendous research efforts in universities and pharmaceutical
companies, effective drugs are still lacking for the treatment of Alzheimer's disease (AD). The …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …

Conspectus With the increase of life expectancy of humans in more than two-thirds of the
countries in the World, aging diseases are becoming the frontline health problems …

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
around the world. Even though the causes of AD are not completely understood due to its …

Neurodegenerative diseases (NDDs) have been increasing in incidence in recent years and
are now widespread worldwide. Neuronal death is defined as the progressive loss of …

Oxidative stress is linked to the etiology of Alzheimer's disease (AD), the most common
cause of dementia in the elderly. Redox active metal ions such as copper catalyze the …

Cu bound to amyloid‐β (Aβ) peptides can act as a catalyst for the formation of reactive
oxygen species (ROS), leading to neuropathologic degradation associated with Alzheimer's …

Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of
intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) plaque deposits …