Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy

K Sałat - Pharmacological reports, 2020 - Springer
Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Review of the role of the brain in chemotherapy-induced peripheral neuropathy

M Omran, EK Belcher, NA Mohile, SR Kesler… - Frontiers in Molecular …, 2021 - frontiersin.org
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-
limiting side effect of many chemotherapy regimens yet has limited treatments due to …

Pathological mechanisms and therapeutic targets for trigeminal neuropathic pain

P Bista, WL Imlach - Medicines, 2019 - mdpi.com
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation
of the trigeminal nerve or its branches, with both peripheral and central nervous system …

EZH2 regulates spinal neuroinflammation in rats with neuropathic pain

R Yadav, HR Weng - Neuroscience, 2017 - Elsevier
Alteration in gene expression along the pain signaling pathway is a key mechanism
contributing to the genesis of neuropathic pain. Accumulating studies have shown that …

Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies

C Pellacani, G Eleftheriou - Advances in Medical Sciences, 2020 - Elsevier
This review summarizes the adverse effects on the central and/or peripheral nervous
systems that may occur in response to antineoplastic drugs. In particular, we describe the …

Excitatory and inhibitory neuronal signaling in inflammatory and diabetic neuropathic pain

U Breitinger, HG Breitinger - Molecular medicine, 2023 - Springer
Pain, although unpleasant, is an essential warning mechanism against injury and damage
of the organism. An intricate network of specialised sensors and transmission systems …

Mechanism-based pharmacological management of chemotherapy-induced neuropathic pain from preclinical studies to clinical prospective: platinum-based drugs …

N Zafari, M Velayati, M Maftooh… - Current …, 2023 - ingentaconnect.com
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition,
experienced by patients undergoing chemotherapy with some specific drugs, such as …

Neuropathic pain-induced enhancement of spontaneous and pain-evoked neuronal activity in the periaqueductal gray that is attenuated by gabapentin

VK Samineni, LS Premkumar, CL Faingold - Pain, 2017 - journals.lww.com
Neuropathic pain is a debilitating pathological condition that is poorly understood. Recent
evidence suggests that abnormal central processing occurs during the development of …

Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: the role of spinal 5‐HT3 receptors

JT Costa‐Pereira, P Serrão, I Martins… - European Journal of …, 2020 - Wiley Online Library
Chemotherapy‐induced neuropathy (CIN) is a common complication of cancer treatment.
Although CIN is treated with antidepressants that act at serotonin (5‐HT) reuptake, the …

Neurophysiopathological aspects of paclitaxel-induced peripheral neuropathy

R Velasco-González, U Coffeen - Neurotoxicity research, 2022 - Springer
Chemotherapy is widely used as a primary treatment or adjuvant therapy for cancer. Anti-
microtubule agents (such as paclitaxel and docetaxel) are used for treating many types of …