Fibrinolysis in traumatic brain injury: diagnosis, management, and clinical considerations

TN Anderson, DH Farrell… - Seminars in thrombosis …, 2021 - thieme-connect.com
Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic
pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This …

Viscoelastic hemostatic assays and outcomes in traumatic brain injury: a systematic literature review

BH Shammassian, A Ronald, A Smith, M Sajatovic… - World Neurosurgery, 2022 - Elsevier
Background Coagulopathy in traumatic brain injury (TBI) occurs frequently and is associated
with poor outcomes. Conventional coagulation assays (CCA) traditionally used to diagnose …

The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of …

M Hayakawa, T Tagami, D Kudo, K Ono, M Aoki… - Journal of Intensive …, 2023 - Springer
Background The efficacies of fresh frozen plasma and coagulation factor transfusion have
been widely evaluated in trauma-induced coagulopathy management during the acute post …

A metabolomic and proteomic analysis of pathologic hypercoagulability in traumatic brain injury patients after dura violation

JR Coleman, A D'Alessandro, I LaCroix… - Journal of Trauma …, 2023 - journals.lww.com
BACKGROUND The coagulopathy of traumatic brain injury (TBI) remains poorly understood.
Contradictory descriptions highlight the distinction between systemic and local coagulation …

Early administration of fibrinogen concentrate is associated with improved survival among severe trauma patients: a single-centre propensity score-matched analysis

Y Itagaki, M Hayakawa, K Maekawa, T Saito… - World Journal of …, 2020 - Springer
Background Fibrinogen plays an important role in haemostasis during the early phase of
trauma, and low fibrinogen levels after severe trauma are associated with haemostatic …

Fibrinolytic system activation immediately following trauma was quickly and intensely suppressed in a rat model of severe blunt trauma

M Hayakawa, T Tsuchida, Y Honma, A Mizugaki… - Scientific reports, 2021 - nature.com
In severe trauma, excessive fibrinolytic activation is associated with an increase in the
transfusion volume and mortality rate. However, in the first several hours after a blunt …

[HTML][HTML] Hyperfibrinolysis drives mechanical instabilities in a simulated model of trauma induced coagulopathy

AR Gosselin, NJ White, CG Bargoud, JS Hanna… - Thrombosis research, 2022 - Elsevier
Introduction Trauma induced coagulopathy (TIC) is common after severe trauma, increasing
transfusion requirements and mortality among patients. TIC has several phenotypes, with …

The association between D-dimer levels and long-term neurological outcomes of patients with traumatic brain injury: an analysis of a nationwide observational …

G Fujiwara, Y Okada, T Sakakibara, T Yamaki… - Neurocritical Care, 2022 - Springer
Background We evaluated the association between D-dimer (DD) levels and long-term
neurological prognoses among patients with isolated traumatic brain injury. Methods Using …

Relationship between admission coagulopathy and prognosis in children with traumatic brain injury: a retrospective study

C You, S Lu, Y Fu, F Xu - Scandinavian Journal of Trauma, Resuscitation …, 2021 - Springer
Background Coagulopathy in adult patients with traumatic brain injury (TBI) is strongly
associated with unfavorable outcomes. However, few reports focus on pediatric TBI …

Fifteen cases of endoscopic treatment of acute subdural hematoma with small craniotomy under local anesthesia: endoscopic hematoma removal reduces the …

M Katsuki, Y Kakizawa, A Nishikawa… - Neurologia medico …, 2020 - jstage.jst.go.jp
We report cases of acute subdural hematoma (ASDH) treated by endoscopic hematoma
removal with a small craniotomy under local anesthesia. From 2015 to 2019, we …