Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

There is a worldwide epidemic of skeletal diseases causing not only a public health issue
but also accounting for a sizable portion of healthcare expenditures. The vertebrate skeleton …

Abstract Purpose of Review Arthritis defines a large group of diseases primarily affecting the
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …

Cartilage not only plays essential roles in skeletal development and growth during pre-and
postnatal stages but also serves to provide smooth movement of skeletons throughout life …

Wnt signaling affects both bone modeling, which occurs during development, and bone
remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially …

Developing tissues dictate the amount and type of innervation they require by secreting
neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase …

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …

Longitudinal bone growth, achieved through endochondral ossification, is accomplished by
a cartilaginous structure, the physis or growth plate, comprised of morphologically distinct …

The Wnt signalling cascades have essential roles in development, growth and homeostasis
of joints and the skeleton. Progress in basic research, particularly relating to our …

Most of our bones form through the process of endochondral ossification, which is tightly
regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the …