The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

The aim of the present work was to develop 3D discrete element models capable of
simulating the observed flow of glass beads (simple glass spheres) and maize grains …

Highlights•Formulation design comprises complicated stages.•Formulation optimization
requires an exhaustive experimental work.•Computational tools help in formulation …

The mixing processes of equal-sized acrylonitrile butadiene Styrene copolymers beads in a
rotating drum were simulated using the Discrete Element Method (DEM) at different …

Scaling relations for the velocity profile and circulation time, which can be used in design
and scale-up, are of great importance in rotating drums. We conducted simulations by …

Powder mixing is one of the most common unit operations in industries handling powders.
However, due to a lack of scientific knowledge on the behavior of powders inside a mixer …

In the pharmaceutical industry, drum coating is routinely used for the production of film
tablets. In order to produce a high-quality product, it is important to understand this …

Coating of tablets is a common unit operation in the pharmaceutical industry. In most cases,
the final product must meet strict quality requirements; to meet them, a detailed …

In the study of the mixing processes of gravel materials by using the discrete element
method, an appropriate selection of physical and contact parameters is crucial. In this study …