Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that
such plasticity be tightly regulated so that it occurs to the proper extent at the proper time …

Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …

Maternal care in the rat influences hippocampal development, synaptic plasticity and
cognition. Previous studies, however, have examined animals under minimally stressful …

This speculative review serves two purposes. First, it as an extension of the ideas we
developed in a previous review (Diamond et al., Hippocampus, 2004; 14: 281–291), and …

Synaptic plasticity is fundamental to the neural processes underlying learning and memory.
Interestingly, synaptic plasticity itself can be dynamically regulated by prior activity, in a …

Neuronal signal transmission depends on the frequency, pattern, and timing of spike output,
each of which are shaped by spike afterhyperpolarizations (AHPs). There are classically …

Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits
were exposed in a subset (30%) of middle-aged mice that performed below criterion on a …

Accumulations of β-amyloid (Aβ) contribute to neurological deficits associated with
Alzheimer's disease (AD). The effects of Aβ on basal neuronal excitability and learning …

CA1 pyramidal neurons from animals that have acquired hippocampal tasks show increased
neuronal excitability, as evidenced by a reduction in the postburst afterhyperpolarization …

The Bienenstock, Cooper and Munro (BCM) computational model, which incorporates a
metaplastic sliding threshold for LTP induction, accounts well for experience-dependent …