The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Acute myeloid leukemia (AML) is one of the most common types of leukemia in adults. While
complete remission can be obtained with intensive chemotherapy in young and fit patients …

Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal
and haematopoietic cells regulate their function. The steady state HSC niche has been …

The skeleton is a unique structure capable of providing support for the body. Bone
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …

The bone marrow is the home of hematopoiesis and is therefore a hotspot for the
development of hematopoietic diseases. Complex interactions between the bone marrow …

Bone marrow mesenchymal stromal cells (MSCs) constitute one of the important
components of the hematopoietic microenvironmental niche. In vivo studies have shown that …

Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …

Xenotransplantation of patient-derived samples in mouse models has been instrumental in
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …

Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM)
microenvironment, which have been widely implicated in pathways that contribute to …