Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

The developmental programme of embryogenesis is controlled by both genetic and
epigenetic mechanisms. An emerging theme from recent studies is that the regulation of …

Extensive human epidemiologic and animal model data indicate that during critical periods
of prenatal and postnatal mammalian development, nutrition and other environmental stimuli …

Therapeutic cloning, whereby somatic cell nuclear transfer (SCNT) is used to generate
patient-specific embryonic stem cells (ESCs) from blastocysts cloned by nuclear transfer …

Epigenetic modifications constitute a complex regulatory layer on top of the genome
sequence. Pluripotent and differentiated cells provide a powerful system for investigating …

The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to
be associated with epigenetic errors including abnormal DNA hypermethylation. Recently …

Converging lines of evidence from epidemiological studies and animal models now indicate
that the origins of obesity and related metabolic disorders lie not only in the interaction …