Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: biological activity and structural modification

M Wang, H Li, W Liu, H Cao, X Hu, X Gao, F Xu… - European Journal of …, 2020 - Elsevier
Based on the definite therapeutic benefits, such as neuroprotective, cardioprotective,
anticancer, anti-diabetic and so on, the Panax genus which contains many valuable plants …

Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

S Ji, Z Li, W Song, Y Wang, W Liang, K Li… - Journal of Natural …, 2016 - ACS Publications
Traditional herbal medicines have been reported to possess significant bioactivities. In this
investigation, a combined strategy using both phytochemical and biological approaches was …

Modification of natural compounds through biotransformation process by microorganisms and their pharmacological properties

N Rustamova, G Huang, M Isokov, J Movlanov, R Farid… - Fitoterapia, 2024 - Elsevier
The biotransformation of natural compounds by fungal microorganisms is a complex
biochemical process. Tandem whole-cell biotransformation offers a promising, alternative …

[PDF][PDF] Understanding the biocatalytic potential of lipase from Rhizopus chinensis

RBR Valério, ALG Cavalcante, GF Mota… - Biointerface Res Appl …, 2022 - researchgate.net
Lipases occupy the third position in the world market for the sale of the most industrially
used enzymes, being one of the most versatile and promising classes, highlighting the …

Glycybridins A–K, Bioactive Phenolic Compounds from Glycyrrhiza glabra

K Li, S Ji, W Song, Y Kuang, Y Lin, S Tang… - Journal of Natural …, 2017 - ACS Publications
In an attempt to discover bioactive agents from the herbal medicine Glycyrrhiza glabra
(widely known as licorice), 11 new phenolic compounds, glycybridins A–K (1–11), along …

Bioconversion of ecotoxic dehydroabietic acid using Rhodococcus actinobacteria

KM Cheremnykh, NA Luchnikova, VV Grishko… - Journal of hazardous …, 2018 - Elsevier
Actinobactrial strains Rhodococcus erythropolis IEGM 267 and R. rhodochrous IEGM 107
were used to study biodegradation of dehydroabietic acid (DHA), a toxic tricyclic diterpenoid …

The song remains the same. The lab bench dilemma of using shaken flasks in microbial biotransformation experiments

NS de Oliveira, GPL da Silva, O Furlan… - Biocatalysis and …, 2024 - Taylor & Francis
Microbial biotransformation is valuable for obtaining pharmaceutical, nutritional, and
cosmetical potential molecules. Basically, for its realization, only a parental molecule, a …

Gender-related differences in tissue distribution, excretion, and metabolism studies of panaxadiol in rats and anti-inflammatory study

L Xu, S Xiao, JJ Lee, X Li, Y Zhao - Journal of Agricultural and …, 2022 - ACS Publications
In this study, we evaluated gender differences in PD excretion, tissue distribution, and
metabolism in rats. In addition, we also evaluated its anti-inflammatory activity and …

[HTML][HTML] Inhalation of panaxadiol alleviates lung inflammation via inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells

Y Wang, H Wei, Z Song, L Jiang, M Zhang, X Lu… - Journal of Ginseng …, 2024 - Elsevier
Background Lung inflammation occurs in many lung diseases, but has limited effective
therapeutics. Ginseng and its derivatives have anti-inflammatory effects, but their unstable …

Semisynthesis and bioactive evaluation of oxidized products from 20 (S)-ginsenoside Rg3, Rh2, protopanaxadiol (PPD) and their 20 (R)-epimers as cytotoxic agents

J Yang, X Li, T Sun, Y Gao, Y Chen, Y Jin, Y Li - Steroids, 2016 - Elsevier
A series of oxidized products have been systematically semisynthesized from 20 (S)-
ginsenoside Rg 3, Rh 2, 20 (S)-protopanaxadiol (PPD) and their 20 (R)-epimers and the …