In spite of tremendous research efforts we have not yet achieved two of our principal
therapeutic goals in the treatment of Parkinson's disease (PD), to prevent its onward …

Significance: Traumatic brain injury (TBI) and spinal cord injury (SCI) are major causes of
death and long-term disability worldwide. Despite important pathophysiological differences …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Remodeling of cytoskeleton structures, such as microtubule assembly, is believed to be
crucial for growth cone initiation and regrowth of injured axons. Autophagy plays important …

Significant advances have been made in recent years in identifying the genetic components
of Wallerian degeneration, the process that brings the progressive destruction and removal …

Autophagy is a physiological process that helps maintain a balance between the
manufacture of cellular components and breakdown of damaged organelles and other toxic …

The difficulty of obtaining samples from certain human tissues has led to efforts to find
accessible sources to analyze molecular markers derived from DNA. In this study, we look …

Axonal degeneration is a key and early pathological feature in traumatic and
neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal …

Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is
strictly regulated by multiple conserved pathways including the ubiquitin-proteasome …

Autophagy is a cellular catabolic pathway generally thought to be neuroprotective. However,
autophagy and in particular its upstream regulator, the ULK1 kinase, can also promote …