[HTML][HTML] Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses

MB Orr, JC Gensel - Neurotherapeutics, 2018 - Elsevier
Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

Immunomodulatory layered double hydroxide nanoparticles enable neurogenesis by targeting transforming growth factor-β receptor 2

R Zhu, X Zhu, Y Zhu, Z Wang, X He, Z Wu, L Xue… - ACS …, 2021 - ACS Publications
Immune microenvironment amelioration and reconstruction by functional biomaterials has
become a promising strategy for spinal cord injury (SCI) recovery. In this study, we evaluated …

Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

S Kabu, Y Gao, BK Kwon, V Labhasetwar - Journal of Controlled Release, 2015 - Elsevier
Spinal cord injury (SCI) results in devastating neurological and pathological consequences,
causing major dysfunction to the motor, sensory, and autonomic systems. The primary …

Recent advances in the application of two-dimensional nanomaterials for neural tissue engineering and regeneration

A Halim, KY Qu, XF Zhang… - ACS Biomaterials Science …, 2021 - ACS Publications
The complexity of the nervous system structure and function, and its slow regeneration rate,
makes it more difficult to treat compared to other tissues in the human body when an injury …

Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction

ZS Ji, GB Gao, YM Ma, JX Luo, GW Zhang, H Yang… - Biomaterials, 2022 - Elsevier
Generation of a promising antioxidative reagent with superior biocompatibility is urgently
needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the …

Is graphene shortening the path toward spinal cord regeneration?

AF Girão, MC Serrano, A Completo, PAAP Marques - ACS nano, 2022 - ACS Publications
Along with the development of the next generation of biomedical platforms, the inclusion of
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …

Recent advances in nanotherapeutic strategies for spinal cord injury repair

YH Song, NK Agrawal, JM Griffin, CE Schmidt - Advanced drug delivery …, 2019 - Elsevier
Spinal cord injury (SCI) is a devastating and complicated condition with no cure available.
The initial mechanical trauma is followed by a secondary injury characterized by …

[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …