Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …

Alcoholism is a common, heritable, chronic relapsing disorder. GABAA receptors undergo
allosteric modulation by ethanol, anesthetics, benzodiazepines and neurosteroids and have …

Excessive alcohol consumption is one of the leading causes of preventable death in the
United States. Approximately 14% of those who use alcohol meet criteria during their lifetime …

The goal of typology research is to identify subtypes of alcohol dependent (AD) patients
sharing fundamental characteristics and try to match each subtype, with the most precise …

The development of alcohol dependence is posited to involve numerous changes in brain
chemistry (ie, neurotransmission) that lead to physiological signs of withdrawal upon …

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the
mammalian brain. This review sets out to summarize the evidence that variations in genes …

GABAA receptors have important physiological functions, as revealed by pharmacological
studies and experiments involving gene-targeted mouse models, and are the target of …

Alcohol dependence (AD), a genetically influenced phenotype, is extremely costly to
individuals and to society in the United States and throughout the world, contributing to …

Twin, family, and adoption studies have consistently shown that genetic factors play an
important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to …

The chromosome 4 cluster of GABA A receptor genes is predominantly expressed in the
brain reward circuitry and this chromosomal region has been implicated in linkage scans for …