Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

[HTML][HTML] Biomarkers in lung cancer screening: achievements, promises, and challenges

LM Seijo, N Peled, D Ajona, M Boeri, JK Field… - Journal of Thoracic …, 2019 - Elsevier
The present review is an update of the research and development efforts regarding the use
of molecular biomarkers in the lung cancer screening setting. The two main unmet clinical …

[HTML][HTML] Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

R Kotecha, A Takami, JL Espinoza - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cancer chemoprevention involves the use of different natural or biologic agents to inhibit or
reverse tumor growth. Epidemiological and pre-clinical data suggest that various natural …

Recent advances in NMR-based metabolomics

GA Nagana Gowda, D Raftery - Analytical Chemistry, 2017 - ACS Publications
NMR spectroscopy, one of the two major analytical platforms utilized in the metabolomics
field, has witnessed a large number of advances in fundamental studies, methods …

[HTML][HTML] Glutamine addiction and therapeutic strategies in lung cancer

K Vanhove, E Derveaux, GJ Graulus… - International journal of …, 2019 - mdpi.com
Lung cancer cells are well-documented to rewire their metabolism and energy production
networks to support rapid survival and proliferation. This metabolic reorganization has been …

[HTML][HTML] High-resolution metabolomic biomarkers for lung cancer diagnosis and prognosis

S Qi, Q Wu, Z Chen, W Zhang, Y Zhou, K Mao, J Li… - Scientific reports, 2021 - nature.com
Lung cancer is the leading cause of human cancer mortality due to the lack of early
diagnosis technology. The low-dose computed tomography scan (LDCT) is one of the main …

Characterization of triple‐negative breast cancer preclinical models provides functional evidence of metastatic progression

JJ Arroyo‐Crespo, A Armiñán… - … journal of cancer, 2019 - Wiley Online Library
Triple‐negative breast cancer (TNBC), an aggressive, metastatic and recurrent breast
cancer (BC) subtype, currently suffers from a lack of adequately described spontaneously …

[HTML][HTML] Next-generation metabolomics in lung cancer diagnosis, treatment and precision medicine: mini review

L Yu, K Li, X Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer-related death. Next-generation metabolomics is
becoming a powerful emerging technology for studying the systems biology and chemistry of …

[HTML][HTML] Obesity, metabolic factors and risk of different histological types of lung cancer: a Mendelian randomization study

R Carreras-Torres, M Johansson, PC Haycock… - PloS one, 2017 - journals.plos.org
Background Assessing the relationship between lung cancer and metabolic conditions is
challenging because of the confounding effect of tobacco. Mendelian randomization (MR) …

A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment

S Bamji-Stocke, V van Berkel, DM Miller, HB Frieboes - Metabolomics, 2018 - Springer
Introduction Lung cancer continues to be the leading cause of cancer-related mortality
worldwide. Early detection has proven essential to extend survival. Genomic and proteomic …