Brain organoids are stem cell-based self-assembling 3D structures that recapitulate early
events of human brain development. Recent improvements with patient-specific 3D brain …

Cancer stem cells (CSCs), characterized by self-renewal and unlimited proliferation, lead to
therapeutic resistance in lung cancer. In this study, we aimed to investigate the expressions …

Background Tumor stem cells play important roles in the survival, proliferation, metastasis
and recurrence of tumors. We aimed to identify new prognostic biomarkers for lung …

Canonical Wnt signaling plays critical roles in development and tissue renewal by regulating
β-catenin target genes. Recent evidence showed that β-catenin–independent Wnt signaling …

Embryonic stem cells (ESCs) are defined by their ability to self-renew and the potential to
differentiate into all tissues of the developing organism. We previously demonstrated that …

Formerly hailed as “undruggable” proteins, transcription factors (TFs) are now under
investigation for targeted therapy. In cancer, this may alter, inter alia, immune evasion or …

Mouse embryonic stem cells (mESCs) sporadically transition to a transient totipotent state
that resembles blastomeres of the two‐cell (2C) embryo stage, which has been proposed to …

Reprogramming human somatic cells into a pluripotent state, achieved through the
activation of well-defined transcriptional factors known as OSKM factors, offers significant …

Pluripotent stem cells (PSCs) have the potential to differentiate to any of the other organs.
The genome DNA integrity of PSCs is maintained by a high level of transcription for a …

The development and homeostasis of organisms rely on the correct replication,
maintenance and segregation of their genetic blueprints. How these intracellular processes …