Nutrient overload leads to obesity, insulin resistance, and often type 2 diabetes. Whereas
increased fat intake is commonly cited as the major factor in diet-induced dysmetabolic …

The 70kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous
serine/threonine kinases that are activated in response to growth factors, cytokines and …

Activation of 40S ribosomal protein S6 kinases (S6Ks) is mediated by anabolic signals
triggered by hormones, growth factors, and nutrients. Stimulation by any of these agents is …

The proteins eIF-4E BP1 and p70 S6 kinase each undergo an insulin/mitogen-stimulated
phosphorylation in situ that is partially inhibited by rapamycin. Previous work has …

Recent studies have shown that the p70 s6k/p85 s6k signaling pathway plays a critical role
in cell growth by modulating the translation of a family of mRNAs termed 5′ TOPs, which …

The highly homologous 40S ribosomal protein S6 kinases (S6K1 and S6K2) play a key role
in the regulation of cell growth by controlling the biosynthesis of translational components …

The activation of p70s6k is accompanied by a complex series of phosphorylation events. In
this review we propose a model of activation which divides p70s6k into four functional …

Background: The p70 S6 kinase, an enzyme critical for cell-cycle progression through the
G1 phase, is activated in vivo by insulin and mitogens through coordinate phosphorylation at …

Rapamycin has potent immunosuppressive properties reflecting its ability to disrupt cytokine
signaling that promotes lymphocyte growth and differentiation. In IL-2-stimulated T cells …

The ribosomal S6 protein kinase p70 S6 kinase is known for its role in modulating cell-cycle
progression, cell size, and cell survival. In response to mitogen stimulation, p70 S6 kinase …