Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Adult stem cells are fundamental to maintain tissue homeostasis, growth, and regeneration.
They reside in specialized environments called niches. Following activating signals, they …

Insufficient podocyte regeneration after injury is a central pathomechanism of
glomerulosclerosis and chronic kidney disease. Podocytes constitutively secrete the …

Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with
sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In …

Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected
patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of …

Emerging studies have shown that lipids and proteins play versatile roles in various aspects
of aging. High-resolution in situ optical imaging provides a powerful approach to study the …

Systemic inflammation may trigger innate immune memory and persistent changes in
hematopoietic cells through epigenetic mechanisms, though investigating these phenotypes …

Hematopoietic stem cells (HSCs) provide all types of blood cells during the entire life of the
organism. HSCs are mainly quiescent and can eventually enter the cell cycle to differentiate …

Stem cell research has progressed widely and has been receiving a considerable attention
for its advantages and drawbacks. Despite their extensive therapeutic potential in …

Hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic
endothelium via the endothelial-to-hematopoietic transition, are self-renewing, and …