P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP)
binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to …

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …

Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding
sequences, and therefore they are not expected to change the function of the protein in …

To evaluate whether alterations in the multidrug-resistance (MDR)-1 gene correlate with
intestinal MDR-1 expression and uptake of orally administered P-glycoprotein (PGP) …

Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has
a proven safety record when appropriately applied to eliminate weeds. However, over the …

Two types of P-glycoprotein have been found in mammals: the drug-transporting P-
glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The …

P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter,
functions as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and …