Congenital diaphragmatic hernia

A Zani, WK Chung, J Deprest, MT Harting… - Nature Reviews …, 2022 - nature.com
Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by incomplete
closure of the diaphragm and herniation of fetal abdominal organs into the chest that results …

[HTML][HTML] Cellular origins and translational approaches to congenital diaphragmatic hernia

M Jank, F Doktor, A Zani, R Keijzer - Seminars in Pediatric Surgery, 2024 - Elsevier
Abstract Congenital Diaphragmatic Hernia (CDH) is a complex developmental abnormality
characterized by abnormal lung development, a diaphragmatic defect and cardiac …

Small extracellular vesicles from human amniotic fluid samples as promising theranostics

A Costa, R Quarto, S Bollini - International Journal of Molecular Sciences, 2022 - mdpi.com
Since the first evidence that stem cells can provide pro-resolving effects via paracrine
secretion of soluble factors, growing interest has been addressed to define the most ideal …

Exploring new perspectives on congenital diaphragmatic hernia: A comprehensive review

W Renik-Jankowska, A Buczyńska… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Congenital diaphragmatic hernia (CDH) represents a developmental anomaly that
profoundly impacts the embryonic development of both the respiratory and cardiovascular …

[HTML][HTML] Extracellular vesicles from II trimester human amniotic fluid as paracrine conveyors counteracting oxidative stress

G Senesi, L Guerricchio, M Ghelardoni, N Bertola… - Redox Biology, 2024 - Elsevier
Background We previously demonstrated that the human amniotic fluid (hAF) from II
trimester of gestation is a feasible source of stromal progenitors (human amniotic fluid stem …

Role of microRNAs in congenital diaphragmatic hernia-associated pulmonary hypertension

F Pugnaloni, I Capolupo, N Patel, P Giliberti… - International Journal of …, 2023 - mdpi.com
Epigenetic regulators such as microRNAs (miRNAs) have a key role in modulating several
gene expression pathways and have a role both in lung development and function. One of …

Amniotic fluid stem cell extracellular vesicles as a novel fetal therapy for pulmonary hypoplasia: a review on mechanisms and translational potential

F Doktor, L Antounians, RL Figueira… - Stem Cells …, 2025 - academic.oup.com
Disruption of developmental processes affecting the fetal lung leads to pulmonary
hypoplasia. Pulmonary hypoplasia results from several conditions including congenital …

Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles

I Atukorala, N Hannan, L Hui - Journal of Translational Medicine, 2024 - Springer
This review aims to encapsulate the current knowledge in extracellular vesicles extracted
from amniotic fluid and amniotic fluid derived stem/stromal cells. Amniotic fluid (AF) bathes …

Pyroptosis: A Promising Mechanism Linking SARS-CoV-2 Infection to Adverse Pregnancy Outcomes

P Monti, G Solazzo, V Accurti, B Gambitta… - International Journal of …, 2023 - mdpi.com
Pregnancy is characterized by a delicate immune balance; therefore, infectious diseases
might increase the risk of adverse pregnancy outcomes (APOs). Here, we hypothesize that …

MicroRNAs in Small Extracellular Vesicles from Amniotic Fluid and Maternal Plasma Associated with Fetal Palate Development in Mice

X Zhao, X Peng, Z Wang, X Zheng, X Wang… - International Journal of …, 2023 - mdpi.com
Cleft palate (CP) is a common congenital birth defect. Cellular and morphological processes
change dynamically during palatogenesis, and any disturbance in this process could result …