Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers
D Matveychuk, RK Thomas… - Therapeutic …, 2020 - journals.sagepub.com
Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment …
purpose, has garnered marked interest over the past two decades as an emerging treatment …
Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine
C Huang, Z Wu, D Wang, Y Qu, J Zhang, R Jiang… - Molecular …, 2024 - nature.com
Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has
been linked to depression pathology, changes in myelination may be a pivotal mechanism …
been linked to depression pathology, changes in myelination may be a pivotal mechanism …
[HTML][HTML] The role of mGlu2/3 receptor antagonists in the enhancement of the antidepressant-like effect of ketamine
A Pałucha-Poniewiera - Pharmacology Biochemistry and Behavior, 2022 - Elsevier
MGlu 2/3 receptor antagonists produce antidepressant-like effects in animal models of
depression. A number of mechanisms responsible for these actions are convergent to the …
depression. A number of mechanisms responsible for these actions are convergent to the …
Rapid-acting antidepressant drugs modulate affective bias in rats
JK Hinchcliffe, SA Stuart, CM Wood, J Bartlett… - Science translational …, 2024 - science.org
How rapid-acting antidepressants (RAADs), such as ketamine, induce immediate and
sustained improvements in mood in patients with major depressive disorder (MDD) is poorly …
sustained improvements in mood in patients with major depressive disorder (MDD) is poorly …
[HTML][HTML] Chronic lithium treatment ameliorates ketamine-induced mania-like behavior via the PI3K-AKT signaling pathway
RJ Ni, TH Gao, YY Wang, Y Tian, JX Wei… - Zoological …, 2022 - ncbi.nlm.nih.gov
Ketamine, a rapid-acting antidepressant drug, has been used to treat major depressive
disorder and bipolar disorder (BD). Recent studies have shown that ketamine may increase …
disorder and bipolar disorder (BD). Recent studies have shown that ketamine may increase …
Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity
J Guang, H Baker, O Ben-Yishay Nizri, S Firman… - npj Parkinson's …, 2021 - nature.com
Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson's
disease. Many centers employ awake physiological navigation and stimulation assessment …
disease. Many centers employ awake physiological navigation and stimulation assessment …
Molecular mechanisms for the antidepressant-like effects of a low-dose ketamine treatment in a DFP-based rat model for Gulf War Illness
Exposure to organophosphates (OP) during the First Gulf War is among one of the factors for
Gulf War Illness (GWI) development in veterans and it has been challenging to treat GWI …
Gulf War Illness (GWI) development in veterans and it has been challenging to treat GWI …
Assessment of objective and subjective cognitive function in patients with treatment-resistant depression undergoing repeated ketamine infusions
JL Phillips, A Van Geel, P Burhunduli… - International Journal …, 2022 - academic.oup.com
Background Subanesthetic ketamine infusions can elicit rapid and sustained antidepressant
effects, yet the potential cognitive impact of ketamine has not been thoroughly examined …
effects, yet the potential cognitive impact of ketamine has not been thoroughly examined …
A novel application of ketamine for improving perioperative sleep disturbances
B Song, J Zhu - Nature and Science of Sleep, 2021 - Taylor & Francis
Perioperative sleep disturbances are commonly observed before, during, and after surgery
and can be caused by several factors, such as preoperative negative moods, general …
and can be caused by several factors, such as preoperative negative moods, general …
Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate
ACR Ribeiro, FM Jahr, E Hawkins, MM Kronfol… - Life sciences, 2021 - Elsevier
Aims Deployment-related exposures to organophosphate (OP) compounds are implicated
for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the …
for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the …