Psychotic disorders
JA Lieberman, MB First - New England Journal of Medicine, 2018 - Mass Medical Soc
Psychosis Psychosis is a syndrome embedded in several disorders, including schizophrenia
and bipolar disorder with psychotic features. Dopamine and glutamate are implicated in the …
and bipolar disorder with psychotic features. Dopamine and glutamate are implicated in the …
How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete
A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …
Genetic control of RNA splicing and its distinct role in complex trait variation
Most genetic variants identified from genome-wide association studies (GWAS) in humans
are noncoding, indicating their role in gene regulation. Previous studies have shown …
are noncoding, indicating their role in gene regulation. Previous studies have shown …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Genetic mapping of cell type specificity for complex traits
K Watanabe, M Umićević Mirkov, CA de Leeuw… - Nature …, 2019 - nature.com
Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific
transcriptome profiles. Such profiles can be aligned with genome-wide association studies …
transcriptome profiles. Such profiles can be aligned with genome-wide association studies …
Genetic identification of brain cell types underlying schizophrenia
With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …
schizophrenia have not converged on findings that can be confidently used for precise …
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
Impaired tuning of neural ensembles and the pathophysiology of schizophrenia: a translational and computational neuroscience perspective
The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …
functions. When the functions through which neural activity is tuned fail to develop or break …