Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the
generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and …

GMP synthetase (GMPS), a key enzyme in the purine biosynthetic pathway performs
catalysis through a coordinated process across two catalytic pockets for which the …

Over the last four decades the HIV pandemic and advances in medical treatments that also
cause immunosuppression have produced an ever-growing cohort of individuals …

The members of the glutamine amidotransferase (GATase) family catalyze the incorporation
of ammonia within numerous metabolic pathways and can be categorized in two classes …

More than half of the protein-coding genes in bacteria are organized in polycistronic
operons composed of two or more genes. It remains under debate whether the operon …

GMP synthetase catalyses the conversion of XMP to GMP through a series of reactions that
include hydrolysis of Gln to generate ammonia in the glutamine amidotransferase (GATase) …

The Helicobacter pylori Asp‐tRNAA sn/Glu‐tRNAG ln amidotransferase (Gat CAB) utilizes
an uncommonly hydrophilic,~ 40 Å ammonia tunnel for ammonia/ammonium transport …

ABSTRACT Human Guanine Monophosphate Synthetase (hGMPS) converts XMP to GMP,
and acts as a bifunctional enzyme with N‐terminal “glutaminase”(GAT) and C‐terminal …

Histidine is ubiquitous in enzyme active sites but its role is often difficult to ascribe due to
ambiguity of protonation state and complex electrostatic and dynamic effects involved. In this …

Imidazole glycerol phosphate synthase (ImGPS) is a bienzyme complex from histidine
biosynthesis, which consists of the cyclase subunit HisF and the glutaminase subunit HisH …