The role of TBK1 in cancer pathogenesis and anticancer immunity
The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
G Calabrese, C Molzahn, T Mayor - Journal of Biological Chemistry, 2022 - ASBMB
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
[PDF][PDF] Huntington Disease: mechanism of Pathogenesis and recent developments in its therapeutic strategies: a review
One of the leading causes of death apart from cancer is a neurodegenerative disease.
Huntington's disease (HD) is such that affects the neurons resulting from the programmed …
Huntington's disease (HD) is such that affects the neurons resulting from the programmed …
The multiple roles of autophagy in neural function and diseases
Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,
where proteins, lipids, and organelles are degraded and recycled. According to the way the …
where proteins, lipids, and organelles are degraded and recycled. According to the way the …
HD and SCA1: Tales from two 30-year journeys since gene discovery
LM Thompson, HT Orr - Neuron, 2023 - cell.com
One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …
expansion of unstable nucleotide repeats underlies a group of inherited neurological …
[HTML][HTML] TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease
L Herhaus - Matrix Biology, 2021 - Elsevier
Abstract TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a
broad spectrum of functions in cells. These range from innate immunity, inflammation and …
broad spectrum of functions in cells. These range from innate immunity, inflammation and …
GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin
Recent studies demonstrated that the Golgi reassembly stacking proteins (GRASPs),
especially GRASP55, regulate Golgi-independent unconventional secretion of certain …
especially GRASP55, regulate Golgi-independent unconventional secretion of certain …
Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an
expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The …
expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The …
Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease
Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded
CAG repeat in the Huntingtin (HTT) gene that encodes for an expanded polyglutamine …
CAG repeat in the Huntingtin (HTT) gene that encodes for an expanded polyglutamine …
[HTML][HTML] Roscovitine, a CDK inhibitor, reduced neuronal toxicity of mHTT by targeting HTT phosphorylation at S1181 and S1201 in Vitro
H Liu, A McCollum, A Krishnaprakash… - International journal of …, 2024 - mdpi.com
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by
a single mutation in the huntingtin gene (HTT). Normal HTT has a CAG trinucleotide repeat …
a single mutation in the huntingtin gene (HTT). Normal HTT has a CAG trinucleotide repeat …