Recent accumulating researches implicate that non-coding RNAs (ncRNAs) including
microRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNAs) play …

Radiotherapy (RT), or radiation therapy, has been widely used in clinical practice for the
treatment of local advanced gastrointestinal carcinoma. RT causes DNA double-strand …

Background Colorectal cancer (CRC) is one of the most common malignant cancers
globally. Circular RNAs (circRNAs) have been implicated in the development of CRC. In this …

Systemic therapy for muscle-invasive bladder cancer (BC) remains dominated by cisplatin-
based chemotherapy. However, resistance to cisplatin therapy greatly limits long-term …

Rectal cancer (RC) is the leading cause of tumor-related death among both men and
women. The efficacy of immunotherapy for rectal cancer is closely related to the immune …

Background Radioresistance is a primary factor contributing to the failure of rectal cancer
treatment. Immune suppression plays a significant role in the development of …

MicroRNAs (miRs) contribute to biological robustness by buffering cellular processes from
external perturbations. Here we report an unexpected link between DNA damage response …

Extensive research has indicated that miRNAs are crucial for the occurrence and
progression of cancers. miR-451a, involved in breast cancer (BC), is one of the miRNAs …

Activation of acid sphingomyelinase (SMPD1) and the generation of ceramide is a critical
regulator of apoptosis in response to cellular stress including radiation. Endothelial SMPD1 …

Locally advanced rectal cancer (RC) is treated with neoadjuvant chemoradiotherapy (nCRT)
followed by radical surgery. Currently, organ-sparing approaches and/or “watch-and-wait” …