DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

Quinoline is one of the most important and versatile nitrogen heterocycles embodied in
several biologically active molecules. Within the numerous quinolines developed as …

A series of platinum (II) complexes containing dipyridophenazine (dppz) and C-
deprotonated 2-phenylpyridine (N∧ CH) ligands were prepared and assayed for G …

Two G-quadruplex ligands [Pt (La)(DMSO) Cl](Pt 1) and [Pt (Lb)(DMSO) Cl](Pt 2) have been
synthesized and fully characterized. The two complexes are more selective for SK-OV …

Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

The interactions of a series of platinum (II) Schiff base complexes with c‐myc G‐quadruplex
DNA were studied. Complex [PtL1a](1 a; H2L1a= N, N′‐bis (salicylidene)‐4, 5‐methoxy‐1 …

Senescence suppresses tumor growth, while also developing a tumorigenic state in the
nearby cells that is mediated by senescence-associated secretory phenotypes (SASPs). The …

Telomerase is a ribonucleoprotein (RNP) responsible for the maintenance of chromosomal
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …

An iron-catalyzed strategy for the rapid synthesis of indolo [2, 3-c] quinolines has been
developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative …