Potential mechanisms and applications of statins on osteogenesis: Current modalities, conflicts and future directions
Statins are known for their beneficial effects on cardiovascular diseases. Besides the lipid-
lowering properties, statins exert their anabolic effects on the bone by differentiating …
lowering properties, statins exert their anabolic effects on the bone by differentiating …
Journey into bone models: a review
J Scheinpflug, M Pfeiffenberger, A Damerau… - Genes, 2018 - mdpi.com
Bone is a complex tissue with a variety of functions, such as providing mechanical stability
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …
Self-healing DNA-based injectable hydrogels with reversible covalent linkages for controlled drug delivery
Injectable hydrogels represent a valuable tool for the delivery of therapeutic molecules
aimed to restore the functionality of damaged tissues. In this study, we report the design of a …
aimed to restore the functionality of damaged tissues. In this study, we report the design of a …
[HTML][HTML] Octacalcium phosphate: Innovative vehicle for the local biologically active substance delivery in bone regeneration
Disadvantages of conventional drug delivery systems (DDS), such as systemic circulation,
interaction with physiochemical factors, reduced bioavailability, and insufficient drug …
interaction with physiochemical factors, reduced bioavailability, and insufficient drug …
Novel applications of statins for bone regeneration
The use of statins for bone regeneration is a promising and growing area of research.
Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy …
Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy …
Delivery of phenamil enhances BMP-2-induced osteogenic differentiation of adipose-derived stem cells and bone formation in calvarial defects
Bone morphogenetic proteins (BMPs) have been widely used for bone repair in the
craniofacial region. However, its high dose requirement in clinical applications revealed …
craniofacial region. However, its high dose requirement in clinical applications revealed …
Enhanced osteogenesis of adipose-derived stem cells by regulating bone morphogenetic protein signaling antagonists and agonists
Although adipose-derived stem cells (ASCs) are an attractive cell source for bone tissue
engineering, direct use of ASCs alone has had limited success in the treatment of large …
engineering, direct use of ASCs alone has had limited success in the treatment of large …
Facile and simple preparation of pH-sensitive chitosan-mesoporous silica nanoparticles for future breast cancer treatment.
WT Liu, Y Yang, PH Shen, XJ Gao… - Express Polymer …, 2015 - search.ebscohost.com
The nanocarrier is linked to the core and shell by hydrogen bond. This drug delivery system
represents a smart, biodegradable, and pH-sensitive nanocarrier for breast cancer therapy …
represents a smart, biodegradable, and pH-sensitive nanocarrier for breast cancer therapy …
[HTML][HTML] Marine plankton exoskeleton-derived honeycombed hydroxyapatite bone granule for bone tissue engineering
The recovery of biocompatible implantable biomaterials from biowaste is a significant
method for protecting both human health and the environment concerns. This study aimed to …
method for protecting both human health and the environment concerns. This study aimed to …
Simvastatin, dosage and delivery system for supporting bone regeneration, an update review
M Kheirallah, H Almeshaly - Journal of Oral and Maxillofacial Surgery …, 2016 - Elsevier
Objective The purpose of this review is to discuss the dosage, duration and carrier for
simvastatin, and to summarize effects of topical application directly or indirectly for …
simvastatin, and to summarize effects of topical application directly or indirectly for …