Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …

While lymphocytopenia is a common characteristic of patients infected by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the mechanisms responsible for …

A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …

The critical challenge for cancer vaccine‐induced T‐cell immunity is the sustained activation
of antigen cross‐presentation in antigen‐presenting cells (APCs) with innate immune …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain
incompletely understood. Here, we explored the properties of several saponin formulations …

B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

Macrophages are immune cells of haematopoietic origin that provide crucial innate immune
defence and have tissue-specific functions in the regulation and maintenance of organ …

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that
occupies tissues without recirculating. They provide a first response against infections …