“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides
important information about vascular health in a range of brain conditions and diseases …

Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral
haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …

Unhealthy vascular aging promotes atherogenesis, which may lead to significant internal
carotid artery stenosis (CAS) in 5 to 7.5% of older adults. The pathogenic factors that …

Background Neuroimaging of cerebral blood flow (CBF) can inform our understanding of the
pathophysiology of bipolar disorder (BD) as there is increasing support for the concept that …

Alzheimer's disease is associated with a 20–30% reduction in cerebral blood flow. In the
APP/PS1 mouse model of Alzheimer's disease, inhibiting neutrophil adhesion using an …

Background: White matter hyperintensities (WMH) on magnetic resonance imaging (MRI)
have been postulated to be a core feature of Alzheimer's disease. Clinicopathological …

Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory
response critical for maintaining neuronal health, is amongst the earliest pathological …