The effects of MYC on tumor immunity and immunotherapy

J Li, T Dong, Z Wu, D Zhu, H Gu - Cell Death Discovery, 2023 - nature.com
The oncogene MYC is dysregulated in a host of human cancers, and as an important point
of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in …

Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review

E Sadeghi, M Imenshahidi, H Hosseinzadeh - Molecular Biology Reports, 2023 - Springer
Background Nigella sativa and its main bioactive ingredient, thymoquinone, exhibit various
pharmacological activities, including neuroprotective, nephroprotective, cardioprotective …

Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

F Sheikhnia, V Rashidi, H Maghsoudi… - Cancer cell …, 2023 - Springer
Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide.
Thymoquinone (TQ) is a natural compound of Nigella sativa that has been used in traditional …

Thymoquinone inhibits JAK/STAT and PI3K/Akt/mTOR signaling pathways in MV4-11 and K562 myeloid leukemia cells

FA Al-Rawashde, AS Al-Wajeeh, MN Vishkaei… - Pharmaceuticals, 2022 - mdpi.com
Constitutive activation of Janus tyrosine kinase-signal transducer and activator of
transcription (JAK/STAT) and Phosphatidylinositol 3-kinase/Akt/mammalian target of …

Terpenoid-mediated targeting of STAT3 signaling in cancer: an overview of preclinical studies

F Khan, P Pandey, M Verma, TK Upadhyay - Biomolecules, 2024 - mdpi.com
Cancer has become one of the most multifaceted and widespread illnesses affecting human
health, causing substantial mortality at an alarming rate. After cardiovascular problems, the …

Regulatory basis of adipokines leptin and adiponectin in epilepsy: from signaling pathways to glucose metabolism

Y Shan, Y Chen, H Gu, Y Wang, Y Sun - Neurochemical Research, 2023 - Springer
Epilepsy is a common and severe neurological disorder in which impaired glucose
metabolism leads to changes in neuronal excitability that slow or promote the development …

[HTML][HTML] Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer

G Maitisha, J Zhou, Y Zhao, S Han, Y Zhao, A Abliz… - Heliyon, 2023 - cell.com
Lavender essential oil (LEO) is known for its medicinal use in the development of
pharmaceuticals. Further investigations were demonstrated that LEO has many biological …

Effect of AML-exosomes on the cellular and molecular properties of bone marrow mesenchymal stromal cells: expression of JAK/STAT signaling genes

M Nabigol, LK Hajipirloo, B Kuhestani-Dehaghi… - Current Research in …, 2025 - Elsevier
Purpose of study Despite the various therapeutic options introduced for AML treatment,
therapy resistance and relapse are still the main obstacles. It is well known that alterations in …

SKAP1 Is a Novel Biomarker and Therapeutic Target for Gastric Cancer: Evidence from Expression, Functional, and Bioinformatic Analyses

L Zhu, Q Yu, Y Li, M Zhang, Z Peng, S Wang… - International Journal of …, 2023 - mdpi.com
Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Due to the
lack of early symptoms, GC is often diagnosed at an advanced stage when treatment options …

Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells

HA Alshwyeh, WMS Al-Sheikh, A Rasedee… - Molecular & Cellular …, 2024 - Taylor & Francis
In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel
on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell …