Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated
ion channels and function as such in the central and peripheral nervous systems. Recently …

Voltage-gated sodium (NaV) channels are intimately involved in the generation and
transmission of action potentials, and dysfunction of these channels may contribute to …

A specimen of the marine cone snail Conus victoriae collected from a beach in Broome,
Western Australia, by a group from The University of Melbourne led to the discovery of the α …

Pain severely affects the physical and mental health of patients. The need to develop
nonopioid analgesic drugs to meet medical demands is urgent. In this study, we designed a …

In recent years, the advent of computational techniques to predict the potential activity of a
drug interacting with a receptor or to predict the structure of unidentified proteins with …