[HTML][HTML] Natural products chemistry: The emerging trends and prospective goals

RA Khan - Saudi pharmaceutical journal, 2018 - Elsevier
The role and contributions of natural products chemistry in advancements of the physical
and biological sciences, its interdisciplinary domains, and emerging of new avenues by …

A review on the chemical compositions of natural products and their role in setting current trends and future goals

SM Mouneir, A Elhagrasi… - Egyptian Journal of …, 2022 - ejchem.journals.ekb.eg
Natural products chemistry has played a significant role in the advancement of physical and
biological sciences and its interdisciplinary fields due to its unique applications and …

In-silico screening and identification of phytochemicals from Centella asiatica as potential inhibitors of sodium-glucose co-transporter 2 for treating diabetes

MAB Macalalad, AA Gonzales III - Journal of Biomolecular …, 2022 - Taylor & Francis
Abstract Sodium-glucose co-transporter 2 (SGLT-2) is a major transport protein responsible
for reabsorption of glucose from the kidney back to the bloodstream. Inhibiting this protein …

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

K Day, JD Schneible, AT Young, VA Pozdin… - Journal of Materials …, 2020 - pubs.rsc.org
The impact of next-generation biorecognition elements (ligands) will be determined by the
ability to remotely control their binding activity for a target biomolecule in complex …

Structure-based identification of potential novel inhibitors targeting FAM3B (PANDER) causing type 2 diabetes mellitus through virtual screening

G Lanka, R Bathula, M Dasari, S Nakkala… - Journal of Receptors …, 2019 - Taylor & Francis
Type 2 diabetes mellitus is a metabolic disorder that requires potent therapeutic
approaches. The FAM3B is a cytokine-like protein also referred to as PANcreatic-DERrived …

An industrially applied biocatalyst: 2-Deoxy-d-ribose-5-phosphate aldolase

H Fei, C Zheng, X Liu, Q Li - Process Biochemistry, 2017 - Elsevier
Deoxy-d-ribose-5-phosphate aldolase (DERA) belongs to the family of lyases and can form
C–C bonds to generate multiple chiral centers, thus providing an interesting route to …

In Silico Design and Investigation of Novel Thiazetidine Derivatives as Potent Inhibitors of PrpR in Mycobacterium tuberculosis

U Dasmahapatra, S Rajasekhar… - Chemistry & …, 2023 - Wiley Online Library
Tuberculosis is one of the most life‐threatening acute infectious diseases diagnosed in
humans. In the present investigation, a series of 16 new disubstituted 1, 3‐thiazetidines …

[HTML][HTML] Allosteric inhibition of topoisomerase I by pinostrobin: Molecular docking, spectroscopic and topoisomerase I activity studies

A Jadaun, N Subbarao, A Dixit - Journal of Photochemistry and …, 2017 - Elsevier
Cancer, the second major cause of mortality trailing the cardiovascular diseases, is a
multifactorial heterogeneous disease and growing public health problem worldwide. Owing …

Discovery of Pongol, the Furanoflavonoid, as an inhibitor of CDK7/Cyclin H/MAT1 and its preliminary structure–activity relationship

D Bhurta, SB Bharate - ACS omega, 2022 - ACS Publications
Natural products have been a great source of leads for cancer drug discovery. The cyclin-
dependent kinases (CDKs) play a vital role in the initiation and progression of cancer. The …

Discovery of a potent candidate for ret-specific non-small-cell lung cancer—a combined in silico and in vitro strategy

P Ramesh, WH Shin, S Veerappapillai - Pharmaceutics, 2021 - mdpi.com
Rearranged during transfection (RET) is a tyrosine kinase oncogenic receptor, activated in
several cancers including non-small-cell lung cancer (NSCLC). Multiple kinase inhibitors …